Koch's postulates

fastrack index




The established rule in 1890 stands as substantially correct 

so its the go too

the four ( 4 ) Koch's Postulates 




















Bio



Heinrich Hermann Robert Koch was a German physician and microbiologist
As one of the main founders of modern bacteriology, he identified the specific causative agents of tuberculosis, cholera, and others









Koch Postulates



Koch's postulates are four criteria designed to establish a causative relationship between a microbe and a disease. 


The postulates were formulated by Robert Koch and Friedrich Loeffler in 1884,
based on earlier concepts described by Jakob Henle, and refined and published by Koch in 1890



Koch's Postulates to Identify the Causative Agent of an Infectious Disease



Koch's 4

Four criteria that were established by Robert Koch to identify the causative agent of a particular disease, these include:
  1. the microorganism or other pathogen must be present in all cases of the disease
  2. the pathogen can be isolated from the diseased host and grown in pure culture
  3. the pathogen from the pure culture must cause the disease when inoculated into a healthy, susceptible laboratory animal
  4. the pathogen must be reisolated from the new host and shown to be the same as the originally inoculated pathogen




However, Koch's postulates have their limitations and so may not always be the last word. They may not hold if:

The particular bacteria (such as the one that causes leprosy) cannot be "grown in pure culture" in the laboratory.
There is no animal model of infection with that particular bacteria.

A harmless bacteria may cause disease if:
  • It has acquired extra virulence factors making it pathogenic.
  • It gains access to deep tissues via trauma, surgery, an IV line, etc.
  • It infects an immunocompromised patient.
  • Not all people infected by a bacteria may develop disease-subclinical infection is usually more common than clinically obvious infection.
Despite such limitations, Koch's postulates are still a useful benchmark in judging whether there is a cause-and-effect relationship between a bacteria (or any other type of microorganism) and a clinical disease.












What does the first of Koch's postulates state quizlet?

What is Koch's first postulate? The microorganism must be present in all cases of disease. ... The pathogen grown in pure culture must cause disease when placed in a healthy animal.






What is number 2 of Koch's postulates?

Koch's postulates are as follows: The bacteria must be present in every case of the disease. The bacteria must be isolated from the host with the disease and grown in pure culture. The specific disease must be reproduced when a pure culture of the bacteria is inoculated into a healthy susceptible host.









Gold Standard



added 23/4/20  

Gold standard test
In medicine and statistics, a gold standard test is usually the diagnostic test or benchmark that is the best available under reasonable conditions. 
Other times, a gold standard is the most accurate test possible without restrictions
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The 4 postulates were formulated in 1890 by Robert Koch to establish the principal rules recognising a disease https://lnkd.in/gDiY2F8#TOC-Koch-Postulates








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